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W. Roy Smythe, M.D.
| POSITION TITLE Assistant Surgeon and Assistant Professor of Surgery Department of Thoracic and Cardiovascular Surgery M.D. Anderson Cancer Center, Houston, TX. |
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Office Address:
The University of Texas M. D. Anderson Cancer
Department of Thoracic and Cardiovascular Surgery
1515 Holcombe Blvd., Box 445, FC9.2006
Houston, Texas 77030
Email: rsmythe@mdanderson.org
(713) 794-4901 Fax
(713) 792-6933 Phone
Academic and Professional Appointments:
2001 - present, Faculty, The Graduate School of Biological Sciences, The University of Texas Health Science Center and Medical School, Houston, Texas
2000-present, Institutional Physician-Scientist, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
1999-present, Consultant Staff Surgeon, Houston Veterans Administration Medical Center Houston, Texas
1998-present, Assistant Professor of Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
1996-1998, Instructor in Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
1990-1996, Assistant Instructor in Surgery, Hospital of the University of Pennsylvania Philadelphia, Pennsylvania
Administrative Appointments:
1999-present, Director-Thoracic Oncology Pathology Seminar, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
1999-present, Graduate Medical Education Committee, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
1992-1998, Operating Room Committee, Hospital of the University of Pennsylvania Philadelphia, Pennsylvania
1992-1995, Medical-Legal Committee, Hospital of the University of Pennsylvania Philadelphia, Pennsylvania
1992-1994, President, Housestaff Association, Hospital of the University of Pennsylvania Philadelphia, Pennsylvania
Licensures/Boards
Pennsylvania State Board of Medical Examiners, MD046441-L, 1993
Texas State Board of Medical Examiners, K6717, 1998
American Board of Surgery, 4123, 1998
American Board of Thoracic Surgery, 5596, 2000
Education:
Texas A&M University School of Medicine, College Station, Texas, M.D. with honors
Baylor University, Waco, Texas, B.S. in Biology
Resident in Cardiothoracic Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 1996-1998
Chief Resident in Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 1995-1996
Clinical Oncology Fellow, American Cancer Society, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 1995-1996
Post Doctoral Research Fellow, Thoracic & Molecular Oncology, Harrison Department of Surgical Research, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 1992-1995
Resident in Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 1990-1996
Intern in Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 1989-1990
Committee Memberships: National and International
Section Editor - The American College of Chest Physicians Lung Cancer Diagnosis and Treatment Guideline Committee, 2000-Present
Scientific Advisory Board Member - The Mesothelioma Applied Research Foundation (MARF), 2001-Present
Society Memberships with Offices Held:
Member, American Association for the Advancement of Science, 1999-Present
Member, International Association for the Study of Lung Cancer, 1999-Present
Member, American Association of Cancer Research , 1999-Present
Senior Member, Association for Academic Surgery, 2001- Present
Member, American Society of Gene Therapy, 2001-Present
Member, American College of Chest Physicians, 2001-Present
Editorships and Editorial Board Memberships:
Associate Editor, The Internet Journal of Cardiothoracic Surgery, 2000-Present
Reviewer, Journal of the National Cancer Institute, 1999-Present
Reviewer, Asian Cardiovascular & Thoracic Annals, 1999-Present
Reviewer, Journal of Thoracic and Cardiovascular Surgery, 1997-Present
Reviewer, International Journal of Cancer, 1996-Present
Reviewer, The Annals of Thoracic Surgery, 1995-Present
Reviewer, Cancer, 2001-Present
Reviewer, Cancer Letters, 2001-present
Reviewer, Radiation Oncology Biology Physics, 2001-present
Honors and Awards:
Institutional Physician-Scientist Award, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, 2000
Wm. J. Inouye Award for Teaching as a Surgical Resident, The University of Pennsylvania, Department of Surgery, Philadelphia, Pennsylvania, 1996
Jonathan E. Rhoads Award for Research as a Surgical Resident, The University of Pennsylvania, Department of Surgery, Philadelphia, Pennsylvania, 1996
Penn Pearls Teaching Award, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 1996
Class of 1993 Teaching Award, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 1993
Humaneness in Medicine Award, Philadelphia County Medical Society, Philadelphia, Pennsylvania, 1991
Penn Pearls of Teaching Award, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 1989
Helen Salyer Anderson Medical, The Outstanding Graduating, Medical Student for Academic Achievement, Texas A&M University College of Medicine, College Station, Texas, 1989
Richard A. Gaines, MD Award, Outstanding Student in Psychiatry, Texas A&M University College of Medicine, College Station, Texas, 1989
Raleigh R. White, MD Award, Outstanding Student in Surgery, Texas A&M University College of Medicine, College Station, Texas, 1989
Academic Excellence Scholarships, Texas A&M University College of Medicine, College Station, Texas, 1989
Charles A. Dana Foundation Scholarship, The University of Pennsylvania, Philadelphia, Pennsylvania, 1987-1988
Seleted Recent Publications (pertaining to lung cancer and mesothelioma only)
Putnam, J.B., Jr., Walsh, G.L., Swisher, S.G., Roth, J.A., Suell, D.M., Vaporciyan, A.A., Smythe, W.R., Merriman, K.W., and DeFord, L.L. Outpatient management of malignant pleural effusion by a chronic indwelling pleural catheter. Ann. Thorac. Surg., 69:369-75, 2000.
Smythe, W.R., Bridges, N.D., Gaynor, J.W., Nicolson, S., Clark, B.J., and Spray, T.L. Bilateral sequential lung transplant for ectodermal dysplasia. Ann. Thorac. Surg., 70:654-656, 2000.
Mohiuddin, I., Cao, X., and Smythe, W.R. Sodium butyrate markedly augments proapoptotic gene therapy via alterations in bcl-3 family protein expression. Surgical Forum 51:118-120, 2000.
Walsh, G.L., Davis, B.M., Swisher, S.G., Vaporciyan, A.A., Smythe, W.R., Merriman, K.W., Roth J.A., and Putnam, J.B., Jr. A single-institutional multidisciplinary approach to primary sarcomas involving the chest wall requiring full thickness resections. J. Thorac. Cardiovasc. Surg. 121:48-60, 2001.
Pataer, A., Smythe, W.R., Yu, R., Fang, B., McDonnell, T., Roth, J.A., and Swisher, S.G. Adenovirus mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J. Thorac. Cardiovasc. Surg., 121:61-67, 2001.
Smythe, W.R., Estrera, A., Swisher, S.G., Merriman, K.W., Walsh, G.L., Putnam, J.B., Vaporciyan, AA, and Roth J.A. Development of non-small cell carcinoma following treatment for small-cell carcinoma: results of surgical resection. Ann. Thorac. Surg. 71(3):962-6, 2001.
Siegenthaler, M., Pisters, K., Merriman, K., Swisher, S., Roth. J., Walsh, G., Vaporciyan, A., Smythe, W.R., and Putnam J. Preoperative Chemotherapy For Lung Cancer Does Not Increase Surgical Morbidity. Ann Thorac. Surg, 71:1105-12, 2001.
Mohiuddin I, Cao X, Fang B, Nishizak M, Smythe WR. Significant Augmentation of Pro- Apoptotic Gene Therapy by Pharmacologic bcl-xl Down-regulation in Mesothelioma. Cancer Gene Therapy 8; 547-554, 2001.
Smythe, W.R. Treatment of Stage I and II Lung Cancer. Cancer Control: Journal of the Moffitt Cancer Center, 2001.
Journal Articles In Press
Vaporciyan, A.A., Merriman, K.W., Ece, F., Roth, J.A., Smythe, W.R., Swisher, S.G., Walsh, G.L., Nesbitt, J.C., and Putnam, J.B., Jr. Impact of timing of smoking cessation on pulmonary morbidity after pneumonectomy. Ann. Thorac. Surg, 2001.
Ajani J, Komaki R, Putnam JB, Walsh G, Nesbitt J, Pisters P, Lunch P, Vaporcian, Smythe WR, Lahoti S, Raijman I, Swisher S, Martin F, Roth J. A Three-Step Preoperative Strategy of Induction Chemotherapy then Chemoradiation Followed by Patients with Potentially Resectable Carcinoma of the Esophagus. Journal of Clinical Oncology, 2001.
Cao X, Mohuiddin I, Ece F, Mc Conkey D, Smythe WR., Histone Deacetylase Inhibitor Down-Regulation of bcl-xl Gene Expression Leads to Apoptotic Cell Death in Mesothelioma. American Journal of Respiratory Cell and Molecular Biology, 2001.
Han X.Y.,Nguyen K.U., Smythe W.R., Ordonez N.G., Jacobson K.C., Tarrand J.J. Pulmonary Granuloma Caused By Pseudomonas andersonii sp. Nov. The American Journal of Clinical Pathology, 2001.
Swisher S.G., Wynn P., Putnam J.B., Mosheim M. P., Correa A.M., Komaki R. R., Ajani J. A., Smythe W. R., Vaporciyan A.A., Roth J. A., Walsh G.L. Is Salvage Esophagectomy Indicated for Recurrent Tumors Following Definitive Chemoradiation? The Journal of Thoracic and Cardiovascular Surgery, 2001
Smythe W.R., Mohuiddin I, Ozveran M, Cao X. Antisense Therapy For Malignant Mesothelioma Utilizing Oligonucleotides Targeting the bcl-xl Gene Product. The Journal of Thoracic and Cardiovascular Surgery, 2001.
Mohiuddin I, Cao X, Ozveran M, Zumstein L, Chada S, Smythe WR. PTEN Over expression Engenders Cellular Death In Human Malignant Mesothelioma Cells Via Inhibition of AKT Phosphorylation. Annals of Surgical Oncology, 2001.
Smythe, W.R., The First American Textbook of Surgery. Annals of Surgery, 2001.
Khuri F, Smythe W.R. Current Treatment of Mesothelioma: Commentary. Oncology, 2001.
Abstracts published
Smythe. W.R., Lebel, E., Pilewski, J., Bavaria, J.E., Kaiser, L.R., and Albelda, S.M. Integrins and nodal metastasis in non-small cell lung cancer. The 3rd Annual Penn State/Johns Hopkins/University of Pennsylvania Cardiothoracic Research Symposium Competition, 1993.
Smythe, W.R., Lebel, E., Litzky, L., Bavaria, J.E., Kaiser, L.R., and Albelda, S.M. Angiogenesis and nodal metastasis in non-small cell lung carcinoma. The International Conference-American Thoracic Society/American Lung Association. San Francisco, California, May 1993.
Smythe, W.R., Depaolo, R., Gerwirtz, A., Kaiser, L.R., and Albelda, S.M. Antisense therapy for malignant pleural mesothelioma. The 2nd Annual International Mesothelioma Interest Group Meeting. San Francisco, California, May 1993.
Smythe, W.R., Albelda, S.M., Wilson, J.M., Pilewski, J., Kaiser, L.R. Successful gene transfer using adenoviral vectors inhuman malignant mesothelioma. The 30th Annual Meeting of the Society of Thoracic Surgeons. New Orleans, Louisiana, February 1994.
Smythe, W.R., Kaiser, L.R., Gewitz, A.M., Hwang, H., and Albelda, S.M. C-myb antisense oligonucleotide therapy using therapy inhibits growth of human malignant mesothelioma. The 47th Annual Cancer Symposium Meeting of the Society of Surgical Oncology. Houston, Texas, March 1994.
Smythe, W.R., Hwang, H., Amin, K., Wilson, J.M., Albelda, S.M., and Kaiser, L.R. Gene therapy using adenoviral vector transfer of the HSV-thymidine kinase gene as an approach for treatment of human malignant mesothelioma. The 74th Annual Meeting of the American Association for Thoracic Surgery. New York, New York, April 1994.
Hwang, H.C., Smythe, W.R., Eck, S.L, Wilson, J.M., Kaiser, L.R., and Albelda, S.M. Treatment for human malignant mesothelioma utilizing recombinant adenovirus transfer of the HSV-thymidine kinase gene. The Clinical Research Meeting of the AAP/ASCI/AFCR, Baltimore Maryland, April 1994.
Smythe, W.R., Hwang, H., Amin, K., Wilson, J.M., Kaiser, L.R., and Albelda, S.M. Gene therapy for human malignant mesothelioma utilizing adenoviral vector transfer of the HSV-thymidine kinase gene The International Meeting of the American Thoracic Society/American Lung Association, Boston, Massachusetts, May 1994.
Smythe, W.R., Amin, K.M., Hwang, H.M., Morris, J.F., Rauscher, F.J., Kaiser, L.R., and Albelda, S.M. The Wilms tumor gene is selectively expressed in malignant pleural mesothelioma. The International Meeting of the American Thoracic Society/American Lung Association, Boston Massachusetts, May 1994.
Smythe, W.R., Hwang, H.C, Amin, K, Wilson, J.M., Eck, S.L, Albelda, S.M., and Kaiser, L.R. Eradication of experimental human mesothelioma utilizing recombinant adenvirus HSVtk gene transfer. The University of Pennsylvania Cancer Center Annual Scientific Session and Retreat, Philadelphia, Pennsylvania, April 1994.
Smythe, W.R, Hwang, H.C., Amin, K., Wilson, J.M., Eck, S.L., Albelda SM, and Kaiser, L.R. Eradication of human malignant mesothelioma utilizing recombinant adenovirus transfer in an in vivo xenograft model. The Xth Biennial Meeting of the Micheal E. Debakey International Surgical Society, Houston Texas, May 1994.
Smythe, W.R., Hwang, H.C., Amin, K., Wilson, J.M., Eck, S.L., Albelda, S.M., and Kaiser, L.R. Treatment of mesothelioma utilizing recombinant adenovirus transfer of the HSVtk gene. The 7th Annual Conference on Lung Cancer/IASLC, Colorado Springs, Colorado, June 1994
Smythe, W.R., Hwang, H.C., Amin, K., Wilson, J.M., Eck, S.L., Albelda, S.M., and Kaiser, L.R. Significant survival benefit following adenovirus-mediated gene therapy for experimental human malignant mesothelioma. The 80th Annual surgical Forum, American College of surgeons Meeting, Chicago Illinois, October 1994.
Smythe WR, Hwang, H.C., Elshami, A.A., Amin, K., Wilson, J.M., Albelda, S.M., and Kaiser LR. Adenovirus-medicated gene therapy for malignant mesothelioma. The 47th Annual Meeting of the Pennsylvania Association for Thoracic Surgery, Longboat Key Florida, September 1994.
Albelda, S.M., Zhang, H.B., Elshami, A.A., Kucharczuk, J., Smythe, W.R., Hwang, H.C., Amin, K., and Kaiser, L.R. Successful treatment of malignant mesothelioma in an immunocompetent rat model using adenovirus containing the HSVtk gene. The Cold Spring Harbor Meeting on Gene Therapy, Cold Spring Harbor New York, September 1994.
Smythe, W.R., Zhang, H.B., Hwang, H.C., Elshami, A.A., Kucharczuk, J., Amin, K., Albelda, S.M., and Kaiser, L.R. Successful treatment of an immunocompetent model of malignant pleural mesothelioma utilizing adenovirus-mediated gene therapy. The 31st Annual Meeting of the Society of Thoracic Surgeons. Palm Springs, California, January 1995.
Hwang, H.C, Kucharczuk, J., Smythe, W.R., Elshami, A., Zhang, H., Amin, K., Williams, J., Litzky, L., Albelda, S., and Kaiser L. Gene therapy for malignant mesothelioma: viral dose-response and treatment of bulky disease. The 48th Annual Cancer Symposium of the society of Surgical Oncology, Boston Massachusetts, March 1995.
Litzky, L.A., Mooney, A.M., Amin, K.A., Smythe, W.R., Morris, J.M., Pass, H.I., Rodeck, U., Rauscher, F.J., Kaiser, L.R., and Albelda SM. The Wilms tumor gene product is a useful marker for the diagnosis of malignant mesothelioma. United States and Canadian Academy of Pathology Meeting, 1995.
Kucharczuk, J., Elshami, A., Smythe, W.R., Zhang, H., Amin, K., Litzky, L., Albelda, S., and Kaiser, L. Adenoviral mediated gene therapy is effective in the treatment of pleural based malignant mesothelioma. Society of University Surgeons Meeting, Denver Colorado, February 1995.
Kucharczuk, J., Elshami, A., Zhang, H., Smythe, W.R., Hwang, H., Tomlinson, J., Amin, K., Litzky, L., Albelda, S., and Kaiser, L. A pleural model of malignant mesothelioma in Fisher rats. The International Meeting of the American Thoracic Society/American Lung Association, Seattle, Washington, May 1995.
Elshami, A., Kucharczuk, J., Zhang, H., Smythe, W.R., Hwang, H., Amin, K., Litzky, L., Kaiser, L., and Albelda S. Treatment of malignant pleural mesothelioma in an immunocompetent rat model utilizing adenovirus-mediated gene therapy-efficacy and toxicity studies. The International Meeting of the American Thoracic Society/American Lung Association, Seattle, Washington, May 1995.
Kaiser, L.R., Smythe, W.R., Kucharczuk, J., Elshami, A.A., and Albelda, S.M. Adenovirus- Mediated Gene Therapy for Malignant Mesothelioma: A Comparison of Immunodeficient Immunocompetent Tumor Models. The 115th Annual Meeting of the American Surgical Association, Chicago, Illinois, April 1995.
Sterman, D.H., Treat, J., Smythe, W.R., Elshami, A., Kucharczuk, J.C., Wilson, J.M., Litzky, L.A., Kaiser, L.R., and Albelda, S.M.: A Phase I Clinical Trial of Gene Therapy for Malignant Mesothelioma: Preliminary Findings, The American College of Chest Physicians (ACCP) Meeting, New York City, New York, October 1995.
Kucharczuk, J., Elshami, A., Sterman, D.H., Smythe, W.R., Amin, K., Litzky, L.A., Albelda, S.M., and Kaiser, L.R. Safety of intrapleural administration of recombinant adenovirus: A prelude to phase I clinical trails of gene therapy for treatment of patients with malignant mesothelioma. The Pennsylvania Association for Thoracic Surgery, 33rd Annual Meeting, Philadelphia, Pennsylvania, September 1995.
Smythe, W.R., Hwang, H.C., Elshami, A.A., Kucharczuk, J., Amin, K.A., Kaiser, L.R., and Albelda, S.M. Treatment of xenograft models of human malignant mesothelioma utilizing adenovirus-mediated gene therapy. The Third International Mesothelioma Interest Group Meeting, Paris France, September 1995.
Kucharczuk, J., Elshami, A.A., Sterman, S., Smythe, W.R., Amin, K.M., Litzky, L.A., Albelda, S.M., and Kaiser, L.R. Adenoviral mediated gene transfer: effective strategy to reduce tumor burden in an immunocompetent model of pleural based mesothelioma. The Third International mesothelioma Interest Group Meeting, Paris France, September 1995.
Elshami, A.A., Kucharczuk, J.C., Sterman, D.H., Smythe, W.R., Amin, K.M., Litzky, L.A., Kaiser, L.R, and Albelda, S.M. Adenovirus-mediated gene therapy for malignant mesothelioma: a comparison of immunosuppressed, immunodeficient and immunocompetent tumor models. The Third International Mesothelioma Interest Group Meeting, Paris France, September 1995.
Sterman, D., Kucharczuk, J., Elshami, A., Smythe, W.R., Amin, K., Zhang, H., Litzky, L., Kaiser, L., and Albelda, S. Safety of intrapleural adenoviral gene therapy: prelude to clinical trial for malignant mesothelioma. The Third International Mesothelioma Interest Group Meeting, Paris France, September 1995.
Amin, K.M, Mooney, A.M., Smythe, W.R., Morris, J.M., Pass, H.I., Rodeck, U., Kaiser, L.R., Albelda, S.M., and Litzky, L.A. The expression of WT1 in malignant mesothelioma and its utility in the differential diagnosis of pleural-based lesions. The Third International Mesothelioma Interest Group Meeting, Paris France, September 1995.
Kucharczuk, J.C., Elshami, A.A., Smythe, W.R., Zhang, H.B., Amin, K.A., Litzky, L.A., Albelda, S.M., and Kaiser, L.R. Adenoviral mediated gene transfer is effective in the treatment of pleural based malignant mesothelioma. The Society of University Surgeons Thirty-seventh Annual University Surgical Resident's Conference. Denver, Colorado, February 11, 1995.
Wood, J., Sterman, D., Smythe, W., Kucharczuk, J., Elshami, A., Risk, N., Amin, K., Litzky, L., Molmnar-Kimber, K., Roberts, J., Albelda, S., and Kaiser L. Suramin inhibits the growth of malignant mesothelioma in vitro and in a murine xenograft model. The International Meeting of the American Thoracic society/American Lung Association, New Orleans, Louisiana, May 1996.
Smythe, W.R., Wahfsi, D., Bavaria, J.E., Albelda, S.M., and Kaiser, L.R. Integrin expression predicts recurrence in non-small cell lung carcinoma. The 33rd Annual Meeting of the Society of Thoracic Surgeons. San Diego, California, February 1997.
Smythe, W.R., Kucharczuk, J.C., Elshami, A.A., Albelda, S.M., and Kaiser, L.R. Gene therapy for malignant mesothelioma: Preclinical toxicity leading up to a human clinical trail. The 77th Annual Meeting of the American Association for Thoracic Surgery, Washington, DC May 1997.
Smythe, W.R., Bavaria, J.E., Pocchetino, A., Wahl, P., Kotloff, R., Palevsky, H., Kaiser, L.R., and Rosengard B. Short term cytolytic therapy markedly reduces early rejection and improves survival in human lung transplant recipients. The American Society for Transplant Surgery Meeting, Chicago, Illinois 1997.
Putnam, J.B., Roth, J.A., Walsh, G.L., Swisher, S.G., Vaporciyan, A.A., Smythe, W.R., Willis, K.D., Johnson, G., and DeFord, L.L. Chronic Indwelling Pleural Catheter (PleurxÒ) for Cost Effective Management of Malignant Pleural Effusions. 11th MASCC International Symposium, Nice France. February 19, 1999.
Swisher, S., DeFord, L., Merriman, K., Hunt, K., Walsh, G., Vaporicyan, A., Smythe, R., Morris, M., Roth, J., and Putnam J. Impact of operative volume on morbidity, mortality and hospital usage following esophagectomy for esophageal cancer. 25th Western Thoracic Surgical Society Meeting, Lake Tahoe, California 1999.
Siegenthaler, M., Pisters, K., Merriman, K., Swisher, S., Roth. J., Walsh, G., Vaporciyan, A., Smythe, W., and Putnam J. Preoperative Chemotherapy For Lung Cancer Does Not Increase Surgical Morbidity. 36th Annual Meeting of the Society of Thoracic Surgeons, New Orleans, Louisiana 2000.
Walsh, G.L., Davis, B.M., Swisher, S.G., Vaporciyan, A.A., Smythe, W.R., Roth J.A., and Putnam JB. A single institution, multidisciplinary approach to primary sarcomas involving the chest wall requiring full thickness resections. 80th Annual Meeting of the American Association for Thoracic Surgery, Toronto, Ontario 2000.
Putnam, J.B., Benjamin, R.S., Rha, S.J., Walsh, G.L., Swisher, S.G., Vaporciyan A.A., Smythe, W.R., and Roth, J.A. Early Results of Isolated Single Lung Perfusion for Treatment of Unresectable Sarcomatous Metastases. 80th Annual meeting of the American Association for Thoracic Surgery, Toronto, Ontario 2000.
Shin, D.M., Smythe, W.R., Fossella, F.V., Swisher, S.G., Shin, H.J., Lu, C., Khuri, F.R., Yalamanchili, A., Hong, W.K., and Khokhar, AR. Pathologic response with lipsomal-entrapped cisplatin analog (L-NDDP) administered in patients with malignant pleural mesothelomia: phase II clinical study. 9th World Conference on Lung Health and European Respiratory Society Annual Congress, Florence, Italy, 2000.
Mohiuddin, I., Cao, X., and Smythe, W. "Sodium Butyrate Markedly Augments Pro-Apoptotic Gene Therapy Via Alterations in bcl-2 Family Protein Expression. 86th Clinical Congress of the American College of Surgeons. Chicago, IL 2000.
Pataer, A., Smythe, W.R., Yu, R., Fang, B., Mc Donnell, T., Roth, J.A., and Swisher, S.G. "Adenoviral Mediated Bak Gene Transfer Induces Apoptosis in Mesothelioma Cell Lines." 18th Annual meeting of the American Association for Thoracic Surgery, Toronto, Ontario 2000.
Vaporciyan, A., Merriman, K., Ece, F., Roth, J., Smythe, W., Walsh, G., and Putnam, J. Impact of Timing of Smoking Cessation on Pulmonary Morbidity after Pneumonectomy".47th Annual Meeting of the Southern Thoracic Surgical Association, Marco Island, Florida 2000.
Mohuiddin, I.T., Cao, X., and Smythe, W.R. A novel gene therapy system utilizing an enzyme activated anthracycline prodrug and adenoviral transfer of betaglucuronidase and bax. International Gene Therapy of Cancer Meeting, San Diego, CA 2000.
Mohiuddin, I., Cao, X., Roth, J., and Smythe, W. PTEN Over-expression in Mesothelioma Engenders Cellular Death Via AKT Hypophosphorylation. The Society of Surgical Oncology, Washington, DC. 2001
Smythe, W.R., Cao, X.X., and Mohuiddin, I. Antisense Therapy For Malignant Mesothelioma Utilizing Antisense Oligonucleotides Targeting The Bclxl Gene Product. 81st Annual Meeting of the American Association of Thoracic Surgery, San Diego, California 2001.
Smythe, W.R., Inducing Apoptosis in Malignant Mesothelioma: The Critical Role of bclxl Expressions. 92nd Annual Meeting of the American Association for Cancer Research, New Orleans, LA, 2001.
Swisher S, Wynn P, Mosheim M, Putnam J, Komaki R, Ajani J, Smythe W, Vaporciyan A, Roth J, Walsh G. Is Surgical Salvage Indicated for Recurrent esophageal Tumors Following Definitive Chemoradiation. 81st Annual Meeting of the American Association of Thoracic Surgery San Diego, California 2001.
Swisher SG, Ajani JA, Komaki R, Walsh GL, Nesbitt J, Martin F, Lahoti S, Smythe WR, Vaporciyan AA, Putnam JB, Roth JA. Improved Long-Term Survival in Esophageal Cancer Following the Novel Strategy of Induction Chemotherapy Prior to Concurrent Chemoradiation and Surgery. 27th Annual Western Thoracic Surgical Association 2001.
Smythe W, Cao X, Mohiuddin I, Mhashilkar M, Chada S. Effectiveness and Mechanism of mda-7 Gene Therapy for Mesothelioma. American Society of Gene Therapy, Seattle, Washington 2001.
Ozveran M, Cao X, Mohuiddin I, Smythe WR. Histone deacetylase inhibition significantly augments human mesothelioma cellular response to chemotherapeutic agents. 11th Annual European Respiratory Society,Berlin 2001.
Ahamad A, Forster R, Smythe R, Liao Z, Kelly J, Komaki R, Stevens C. IMRT for adjuvant treatment of malignant mesothelioma. American Society for Therapeutic Radiology and Oncology 2001, San Francisco, CA.
Vaporciyan, A.A., Rice, C.D., Correa, A.M., Walsh, G.L., Swisher, S.G., Smythe, W.R., Putnam, J.B., and Roth, J.A. Use of cardiopulmonary bypass for resection of advanced cardiothoracic malignancies, European Society of Thoracic Surgeons 2001, Lisbon, Portugal.
Lipa JE, Ng R, Smythe W, Chevray P. Microvascular Reconstruction of a Massive Thoraco-abdominal Wall Defect Allows Aggressive Resection for Cure. American Society of Reconstructive Microsurgery 2002, Cancun, Mexico.
Stevens C. Smythe WR, Forster K, Ahmad A, Liao Z, Kelly J, Komaki R. Post-extrapleural pneumonectomy hemithorax IMRT for mesothelioma. The Second International Chicago Symoposium on Malignancies of the Head and Neck, September 2001, Chicago, IL.
Cao XX, Ozvaran MK, Miller SD, Gu J, Kim KC, Smythe WR. Tumor Cell Histone Deacetylase Inhibitor exposure engenders a significant increase in adenoviral vector transgene product in a promoter restricted and transgene permissive fashion. The Society of University Surgeons, 2002 (submitted).
Ozvaran MK, Cao XX, Miller SD, Smythe WR. Antisense oligonucleotides directed at the bcl-x gene product significantly augment chemotherapy response in mesothelioma. 82nd Annual Meeting of the American Association for Thoracic Surgery, Washington D.C., 2002 (submitted).
Swisher SG, Kelly K, Putnam JB, Ajani JA, Komaki RR, Aggarwal*B, Correa AM, Gagneja H, Ho L.*, Wayne Hofstetter*, Jason F. Kelly*, Axbal Lara*, Zhongxing Liao*, Patrick M. Lynch*, Macapinlac HA, Smythe WR, Stevens C, Vaporciyan AA, Walsh GL, Yao JC, Roth JA. 82nd Annual Meeting of the American Association for Thoracic Surgery, Washington D.C., 2002 (submitted). Formal Teaching Experience:
Courses taught:
Gene Therapy for Solid Tumors. Biology Graduate Group, Bryn Mawr College, Bryn Mawr, Pennsylvania, October 1997.
Suicide Gene Therapy. The University of Texas Medical School, Graduate School of Biological Sciences, Virology/Gene Therapy Course, Houston, Texas, February 1999.
Suicide Gene Therapy. The University of Texas Medical School Graduate School of Biological Sciences, Virology/Gene Therapy Course, The University of Texas Medical School, Houston, Texas, March 2000.
An Update on Multimodality Therapy for Lung Cancer. Citizen's Medical Center Regional, CME Lecture, Victoria, Texas, August 1999.
Neoadjuvant Therapy of Early Stage Lung Cancer - The S9900 Trial. CME Course, Wichita, Kansas, June 2000.
Suicide Gene Therapy. The University of Texas Medical School Graduate School of Biological Sciences, Virology/Gene Therapy Course, The University of Texas Medical School, Houston, Texas, February 2001.
Local presentations:
Gene Therapy for Cancer. Texas A&M University College of Medicine, Pathology Seminar Series, College Station, Texas, April 1995.
Surgical Treatment of Pleural Diseases. Hermann Hospital / The University of Texas Medical School Pulmonary Grand Rounds, The University of Texas Medical School, Houston, Texas, February 1999.
Multimodality Therapy for Lung Cancer. St. Elizabeth Hospital, Mamie McFaddin Ward Cancer Center, Beaumont, Texas, February 1999.
Multimodality Therapy for Lung Cancer. College Station Medical Center, Cancer Center Grand Rounds, College Station, Texas, April 1999.
Multimodality Therapy for Lung Cancer - A Surgeon's Perspective. Coastal Bend Medical Center, Wharton, Texas, July 1999.
Invited lectures:
Bronchopleural Fistula: Pathogenesis. Cardiothoracic Surgery Grand Rounds, The University of Pennsylvania College of Medicine, Philadelphia, Pennsylvania, April 1997.
Bronchopleural Fistula: Treatment. Cardiothoracic Surgery Grand Rounds, The University of Pennsylvania College of Medicine, Philadelphia, Pennsylvania, August 1998.
Surgery for Advanced Non-Small Cell Lung Cancer. Sarasota Medical Center, Sarasota, Florida, September 1999. Treatment of Advanced Lung Cancer. Columbia Bayshore Hospital, Pasadena, Texas, April 2000.
Treatment Options for Early Stage Lung Cancer-Neoadjuvant Trials. Louisiana Sate University Medical Center, Shreveport, Louisiana, April 2000.
Neoadjuvant Therapy of Early Stage Lung Cancer. St John's Hospital, Joplin, Missouri, May 2000.
Neoadjuvant Therapy for Early Stage Lung Cancer-Neoadjuvant Trials. St. Johns Hospital, Joplin, Missouri, June 2000.
Neoadjuvant Chemotherapy for Early Stage Lung Cancer: Biologic Basis. Regional CME Program, Mobile, Alabama, August 2000.
Early Stage Lung Cancer and the Role of the Pulmonologist: A Multimodality Approach. Schumpert Clinic, Shreveport, Louisiana, October 2000.
Treatment Options for Early Stage Lung Cancer. CHEST 2000 Postgraduate Course. 66th Annual International Scientific Assembly of the American College of Chest Physicians, San Francisco, California, October 2000.
Malignant Pleural Mesothelioma - Paradigm for an Untreatable Malignancy. Baylor College of Medicine Department of Surgery Grand Rounds, Houston, Texas, January 2001.
Treatment of Carcinoma of the Lung-Are we Making Any Progress? Fifteenth Annual Surgical Alumni Society Meeting, Texas A&M University College of Medicine, Scott and White Memorial Hospital and Clinic. Temple, Texas, April 2001.
Molecular Biology and the Modern Surgeon. Fifteenth Annual Surgical Alumni Society Meeting, Texas A&M University College of Medicine, Scott and White Memorial Hospital and Clinic. Temple, Texas, April 2001.
The Role of bcl-xl in Apoptosis in Thoracic Malignancy. University of Texas M. D. Anderson Bone Marrow Transplant Research Symposium. Houston, Texas, May 2001.
Progress and Pitfalls in the Treatment of Malignant Mesothelioma. Advances in Oncology Institutional Grand Rounds, The University of Texas M. D. Anderson Cancer Center, August, 2001.
Preoperative Chemotherapy for Early Stage Non-Small Cell Lung Carcinoma - CHEST 2001 Satellite Symposia. 67th Annual International Scientific Assembly of the American College of Chest Physicians, Philadelphia, PA, November 2001.
Funded Clinical Protocols:
Early Detection of Second Primary Cancers by Sputum Cytology Immunostaining. Collaborator, The University of Texas M. D. Anderson Cancer Center, 1992-Present, ID9-029.
A Phase III Comparison between Concurrent Chemotherapy Plus Radiotherapy and Concurrent Chemotherapy Plus Radiotherapy followed by Surgical Resection for Stage IIIA (N2) Non-Small Cell Lung Cancer. Collaborator, The University of Texas M. D. Anderson Cancer Center, 1994-Present, RTOG93-09.
A Phase II Study of Preoperative 5-FU, Taxol, and Cisplatin followed by Concurrent 5-FU/Cisplatin and Radiotherapy in Patents with Potentially Resectable Carcinoma of the Esophagus or GE Junction. Collaborator, The University of Texas M. D. Anderson Cancer Center, 1996-Present, ID96-189.
An Efficacy Study of Adenoviral Vector Expressing Wildtype P53 (AD-P53) Administered Intralesionally as an Adjunct to Radiation Therapy in Patients with Non-Small Cell Lung Cancer. Collaborator, The University of Texas M. D. Anderson Cancer Center, 1998-Present, GS97-183.
Phase II Clinical Study of Induction Therapy with Intrapleural Liposome Entrapped Cisplatin Analog (L-NDDP) Followed by Surgical Resection and Post-Operative Radiotherapy in Patients with Malignant Pleural Mesothelioma. Collaborator, The University of Texas M. D. Anderson Cancer Center, 1998-Present, ID98-263.
A Phase II Study of Preoperative CPT-11/Cisplatin followed by Concurrent 5-FU/Taxol & Radiotherapy in Patients with Potentially Resectable Carcinoma of the Esophagus or GE Junction. Collaborator, The University of Texas M. D. Anderson Cancer, 1999-Present, DM98-349.
A Feasibility Study to Measure Tumor Oxygenation in Human Non-Small Cell Lung Carcinomas. Co-Investigator, The University of Texas M. D. Anderson Cancer Center, 1999-Present, ID99-052.
A Randomized Study to Evaluate a Polymeric Patch for Sealing Intraoperative Air Leaks Occurring during Pulmonary Resection. Co-Investigator, The University of Texas M. D. Anderson Cancer Center, 1999-Present, THS99-262.
A Randomized Phase III Trial Surgery Alone or Surgery Plus Preoperative Paclitaxel/Carboplatin in Clinical Stage IB (T2NO), II (T1-2N1, T3NO) and Selected IIIA (3N1) Non-Small Cell Lung Cancer (NSCLC). Collaborator, The University of Texas M. D. Anderson Cancer Center, 1999-Present, pending.
A Randomized Phase III Trial Surgery Alone or Surgery Plus Preoperative Paclitaxel/Carboplatin in Clinical State IB (T2NO), II (T1-2N1, T3NO) and Selected IIIA (T3N1) Non-Small Cell Lung Cancer (NSCLC). Collaborator, The University of Texas M. D. Anderson Cancer Center, 1999-Present (pending).
A Phase II, Multi-Center, Open Label, Randomized Study to Compare the Effectiveness and Safety of Intra-Lesional Administration of RPR/IGN 201 in Combination with Taxotere and Radiotherapy versus Taxotere and Radiotherapy Alone in 120 Patients with Locally Advanced Unresectable NSCLC T-215. Collaborator, The University of Texas M. D. Anderson Cancer Center, 1999-Present (pending).
Phase I Evaluation of Intravenous DOTAP:Chol Liposome fus 1 Complex in Patients with Disseminated Non-Small Cell Lung Cancer. Collaborator, The University of Texas, M. D. Anderson Cancer Center, 2000-Present, pending.
A Phase III Randomized study of Amifostine Mucosal Protection for Patients with Favorable Performance Inoperable Stage II-IIIA/B Non-small Cell Lung Cancer (NSCLC) Receiving Sequential Introduction and Concurrent Hyperfractionated Radiotherapy with Paclitaxel and Carboplatin. Collaborator, The University of Texas M. D. Anderson Cancer Center, 2000-Present, RTOG 98-01.
A Phase I Study of Intensity Modulated Radiotherapy (IMRT) for Malignant Pleural Mesothelioma after Extrapleural Pneumonectomy. Study Co-Chairman, The University of Texas M. D. Anderson Cancer Center, 2001-present ID01-318.